BSPGHAN 2021 Virtual Annual Meeting

27- 29 April 2021

A SINGLE CENTRE DESCRIPTION OF IBD PATIENTS WITH NEGATIVE FAECAL CALPROTECTIN AT DIAGNOSIS

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Huda Atta
Huda Atta
3 months ago

Did you have a chance to analyse the outcome of such group?
Was there a significant difference from those who had high fecal calprotectin in inducing the disease remission?

Anna Pigott
Anna Pigott
3 months ago

Very interesting. I’m surprised that there were negative faecal calprotectins in the UC group particularly. There are different assays for faecal calprotectin, I wonder if they vary in significant cut off. You could review what cut off would be appropriate to use. I wonder whether they had significant markers on blood tests? As you say it would be interesting to know more about those with negative results.

Protima Deb
Protima Deb
3 months ago

I do not know our numbers but we too have a few cases also (esp UC) who have flared significantly but have normal FCP during their flare which we have confirmed endoscopically, both macro and histologically. As you say, in such cases going just on fcp alone may have delayed their escalation treatment. So reiterates importance of considering all aspects and not just fcp.
Would be very useful to follow this cohort of patients to check whether their FCP changes in future flare-ups and/or how they correlate with their clinical progress.

Farah Barakat
Farah Barakat
3 months ago

Thank you Harween and the team
Very interesting and valuable study
I eco Dr Deb- observation have been seen in other tertiary centers.
My questions are:
Were all of those patients treatment naive or were they treated with any empirical therapies (ie antibiotic) or as KCH have many liver patients- any immunosuppression?
Are there any in vivo studies that may explain different pathways?

sue protheroe
sue protheroe
3 months ago

great poster and message.
Do you think that doing > 1 FCP is advisable in those who present with a strong clinical picture of IBD in light of your findings?