BSPGHAN 2021 Virtual Annual Meeting

27- 29 April 2021

FIBRATES: AN ADJUVANT THERAPY FOR CHOLESTASIS IN PAEDIATRIC AGE GROUP

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David Campbell
David Campbell
5 months ago

Thank you and I found this very interesting. You do not state what drug and what dose is administered. You mention what class of drug alone, does this imply you used a variety of drugs?
There are other drugs that act on PPARs, do they all have the same effect on bile synthesis?

Huda Atta
Huda Atta
5 months ago
Reply to  David Campbell

Hi David, thank you for your interest. If you can have a look at methods, we gave Fenofibrate 10mg/kg OD. There are studies that compared various types of fibrates but mainly in animals not much in humans

https://scholar.google.co.uk/scholar?q=fenofibrate+vs+bezafibrate+in+cholestasis&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3DkuZz-JtZJsgJ

https://scholar.google.co.uk/scholar?q=fenofibrate+vs+bezafibrate+in+cholestasis&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3D-XNAoiygZu4J

David Campbell
David Campbell
5 months ago
Reply to  Huda Atta

Thank you Huda, in deed I missed that, the dose was very helpful