BSPGHAN 2021 Virtual Annual Meeting

27- 29 April 2021

FIBRATES: AN ADJUVANT THERAPY FOR CHOLESTASIS IN PAEDIATRIC AGE GROUP

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David Campbell
David Campbell
18 days ago

Thank you and I found this very interesting. You do not state what drug and what dose is administered. You mention what class of drug alone, does this imply you used a variety of drugs?
There are other drugs that act on PPARs, do they all have the same effect on bile synthesis?

Huda Atta
Huda Atta
18 days ago
Reply to  David Campbell

Hi David, thank you for your interest. If you can have a look at methods, we gave Fenofibrate 10mg/kg OD. There are studies that compared various types of fibrates but mainly in animals not much in humans

https://scholar.google.co.uk/scholar?q=fenofibrate+vs+bezafibrate+in+cholestasis&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3DkuZz-JtZJsgJ

https://scholar.google.co.uk/scholar?q=fenofibrate+vs+bezafibrate+in+cholestasis&hl=en&as_sdt=0&as_vis=1&oi=scholart#d=gs_qabs&u=%23p%3D-XNAoiygZu4J

David Campbell
David Campbell
18 days ago
Reply to  Huda Atta

Thank you Huda, in deed I missed that, the dose was very helpful