BSPGHAN 2021 Virtual Annual Meeting

27- 29 April 2021

SHOCK COLON

Subscribe
Notify of
6 Comments
Oldest
Newest Most Voted
Inline Feedbacks
View all comments
Jutta Koeglmeier
Jutta Koeglmeier
5 months ago

did any of the children in your series have a post mortem examination and if so what was the finding ?

Alison Campbell
Alison Campbell
5 months ago

Patients 1 and 2 had a post mortem. In neither case did it add information to what was already known.

David Campbell
David Campbell
5 months ago

Thank you Alison.
Can you comment on why the colon might be selectively affected by the NOMI? As it was global, would you expect other segments of ischaemia? Or is this quite predictable?
Were there other drugs that might have played a part (we always look at NSAIDs), or was there a background of some thing that suggested poor colonic health such as constipation?

Alison Campbell
Alison Campbell
5 months ago
Reply to  David Campbell

Thanks for the questions. There are also series of young adults with low output states (obstetric haemorrhage, trauma, sepsis) with colonic NOMI, but no clear explanation. A possible explanation might be variation in arterial supply to the colon via the marginal artery, but this is by no means proven.
Patient 3 in our series did have constipation occasionally managed with movicol. However, as 1 in 10 children have constipation I did not draw any conclusions from this.

Alison Campbell
Alison Campbell
5 months ago

With regard to NSAIDs,no patients in our series were on NSAIDs previously.

David Campbell
David Campbell
5 months ago

Thank you for these responses.