BSPGHAN 2021 Virtual Annual Meeting

27- 29 April 2021

USTEKINUMAB IS AN EFFECTIVE DRUG FOR STEROID- FREE REMISSION IN CHILDREN WITH REFRACTORY IBD AND ANTI TNF-ALPHA INDUCED PSORIASIS

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Rajiv Mohan
Rajiv Mohan
20 days ago

Clear and easy to understand.

David Campbell
David Campbell
18 days ago

This is very interesting and thank you for the presentation. How bad was the psoriasis? Was this standard psoriasis distribution or a variant?
I just don’t recall ever seeing an IBD patient presenting with anti-TNF induced psoriasis. Do yo have any further insights as to whether this may be a cluster phenomenon and related to streptococcal local strain infections? Serology might be helpful, but I only refer to the association between guttate psoriasis and streptococcal infection.
Having an alternative biologic to turn to is very important and a helpful message.

Farah Barakat
Farah Barakat
18 days ago
Reply to  David Campbell

Thank you for your comments.
-Anti-TNF induced psoriasis is well described in adults and paediatric populations.
Infliximab-Induced Psoriasis and Psoriasiform Skin Lesions in Pediatric Crohn Disease and a Potential Association With IL-23 Receptor PolymorphismsSherlock, et al 2013.
-All patients in our study group were seen in deramtology clinic and psoriasis was confirmed. None of them was identified to have skin infection.

-Our study sample was small. Multi-centres study with larger study sample will be ideal.

sue protheroe
sue protheroe
17 days ago

Great poster.
Good to hear – psoriasis induced by anti TNF is difficult.

Does your Trust’s budget fund the cost of Ustekinumab in this age group (while waiting for paediatric studies & research evidence base) ?

Farah Barakat
Farah Barakat
17 days ago
Reply to  sue protheroe

Thank you Dr Protheroe,
Yes, providing they meet the Blueteq criteria – which is a “funding approval form”, trust funds the treatment.
Funding application have been successful for all Ustekinumab patients
In our trust funding approval form required for all biological treatments including anti-TNF

BAN ALKAABY
BAN ALKAABY
17 days ago

Well done Farah, that’s great.
Very pleased for your award, well deserved.