BSPGHAN 2021 Virtual Annual Meeting

27- 29 April 2021

USTEKINUMAB IS AN EFFECTIVE DRUG FOR STEROID- FREE REMISSION IN CHILDREN WITH REFRACTORY IBD AND ANTI TNF-ALPHA INDUCED PSORIASIS

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Rajiv Mohan
Rajiv Mohan
5 months ago

Clear and easy to understand.

David Campbell
David Campbell
5 months ago

This is very interesting and thank you for the presentation. How bad was the psoriasis? Was this standard psoriasis distribution or a variant?
I just don’t recall ever seeing an IBD patient presenting with anti-TNF induced psoriasis. Do yo have any further insights as to whether this may be a cluster phenomenon and related to streptococcal local strain infections? Serology might be helpful, but I only refer to the association between guttate psoriasis and streptococcal infection.
Having an alternative biologic to turn to is very important and a helpful message.

Farah Barakat
Farah Barakat
5 months ago
Reply to  David Campbell

Thank you for your comments.
-Anti-TNF induced psoriasis is well described in adults and paediatric populations.
Infliximab-Induced Psoriasis and Psoriasiform Skin Lesions in Pediatric Crohn Disease and a Potential Association With IL-23 Receptor PolymorphismsSherlock, et al 2013.
-All patients in our study group were seen in deramtology clinic and psoriasis was confirmed. None of them was identified to have skin infection.

-Our study sample was small. Multi-centres study with larger study sample will be ideal.

sue protheroe
sue protheroe
5 months ago

Great poster.
Good to hear – psoriasis induced by anti TNF is difficult.

Does your Trust’s budget fund the cost of Ustekinumab in this age group (while waiting for paediatric studies & research evidence base) ?

Farah Barakat
Farah Barakat
5 months ago
Reply to  sue protheroe

Thank you Dr Protheroe,
Yes, providing they meet the Blueteq criteria – which is a “funding approval form”, trust funds the treatment.
Funding application have been successful for all Ustekinumab patients
In our trust funding approval form required for all biological treatments including anti-TNF

BAN ALKAABY
BAN ALKAABY
5 months ago

Well done Farah, that’s great.
Very pleased for your award, well deserved.